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BOC Sciences
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Product Name:Phenindamine tartrate
CAS:569-59-5
Purity:95% Remarks:Phenindamine tartrate is an antihistamine and anticholinergic drug. It was developed by Hoffman-La Roche in the late 1940s. It is used to treat symptoms of the common cold and allergies, such as sneez
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| Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:Phenindamine Tartrate
CAS:569-59-5
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
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| | phenindamine tartrate Basic information |
| | phenindamine tartrate Chemical Properties |
| Melting point | 160° | | solubility | Sparingly soluble in water; slightly soluble in ethanol (96%); practically insoluble in ether . |
| Toxicity | LD50 in mice (mg/kg): 27 i.v., 170 i.p., 265 orally (Schallek) |
| | phenindamine tartrate Usage And Synthesis |
| Chemical Properties | A white or almost white, voluminous powder. | | Originator | Thephorin ,Roche, US,1947 | | Uses | Histamine H1 receptor antagonist; antihistamine. | | Manufacturing Process | A mixture of 750 grams of 1-methyl-3-benzoyl-4-hydroxy-4-phenylpiperidine and 2,500 cc of 48% hydrobromic acid is refluxed for about 20 minutes. It is then poured into 8 liters of water. An oily precipitate appears which on standing crystallizes. It is filtered and crystallized from about 3.5 liters of alcohol. 2-Methyl-9-phenyl-2,3-dihydrel-pyridindene hydrobromide, MP 201°203°C, is obtained.
A mixture of 680 grams of 2-methyl-9-phenyl-2,3-dihydrol-pyridindene hydrobromide, 6,000 cc of water and about 100 grams of Raney-nickel catalyst is hydrogenated at room temperature and at about 1,000 lb pressure for a period of three hours. The catalyst is filtered. The clear filtrate is treated with a solution of 240 grams potassium thiocyanate in 400 cc of water. A heavy solid precipitates from which the supernatant liquid is decanted.
The residue is dissolved in 10 liters of boiling alcohol with stirring in the presence of nitro gen. The solution is cooled to room temperature under nitrogen, and then allowed to stand overnight. 2-Methyl-9-phenyl-tetrahydro1-pyridindene thiocyanate separates in crystals of MP 188°-189°C. From the concentrated filtrate an additional amount is obtained. The corresponding free base, prepared by treating the slightly soluble thiocyanate in aqueous suspension with sodium hydroxide and extracting with ether, has a MP of 90°91°C. It forms a tartrate of MP 160°C.
The starting material was prepared by reacting acetophenone, methylamine and formaldehyde followed by treatment of the intermediate with sodium hydroxide. | | Brand name | Thephorin (Hoffmann-LaRoche). | | Therapeutic Function | Antihistaminic | | General Description | Phenindamine tartrate,2,3,4,9-tetrahydro-2-methyl-9-phenyl-1H-indeno[2, 1-c]pyridine bitartrate, occurs as a creamy-white powder, usuallywith a faint odor and sparingly soluble in water (1:40). A 2%aqueous solution has a pH of about 3.5. It is most stable inthe pH range of 3.5 to 5.0 and is unstable in solutions of pH 7or higher. Oxidizing substances or heat may cause isomerizationto an inactive form.
Structurally, phenindamine can be regarded as an unsaturatedpropylamine derivative, in that the rigid ring systemcontains a distorted, trans-alkene. Like the other commonlyused antihistamines, it may produce drowsiness and sleepiness;it may also cause a mildly stimulating action in somepatients and insomnia when taken just before bedtime. |
| | phenindamine tartrate Preparation Products And Raw materials |
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