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N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride

N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride Basic information
Product Name:N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride
Synonyms:N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride;Incital;N-(3-Chloropropyl)-1-Methyl-2-phenylethylaMine Hydrochloride;N-(3-Chloropropyl)-α-MethylbenzeneethanaMine Hydrochloride;N-ChloropropylaMphetaMine Hydrochloride;NSC 133749;Pondinil;Pondinol
CAS:5586-87-8
MF:C12H19Cl2N
MW:248.19196
EINECS:2269859
Product Categories:Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:5586-87-8.mol
N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride Structure
N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride Chemical Properties
Melting point 128-130°
Safety Information
MSDS Information
N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride Usage And Synthesis
OriginatorPondinil,Roche,France,1970
UsesThis is a controlled substance (stimulant). Anorexic.
Manufacturing Process9.5 parts of β-chloropropionaldehyde were added slowly, at a temperature of 0°C to a solution of 31.5 parts of 1-phenyl-2-aminopropane in 150 parts of methanol. Thereafter, 0.2 part of platinum oxide was added to the reaction mixture following which the mixture was reacted with hydrogen, in a shaking vessel, until the theoretical quantity of hydrogen had been taken up. When the hydrogenation reaction was completed, the catalyst was removed by filtration and the filtrate neutralized with hydrochloric acid. Subsequently, the filtrate was evaporated to dryness and recrystallized from isopropyl alcohol. The thus-obtained N-(3-chloropropyl)-α-methylphenethylamine hydrochloride melted at 128°C to 130°C.
Therapeutic FunctionAnorexic
N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride Preparation Products And Raw materials
Raw materialsD/L-AMPHETAMINE HYDROCHLORIDE-->β-chloropropionaldehyde-->Hydrogen
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mefenorex N-(3-chloropropyl)-alpha-methylphenethylamine hydrochloride