左色满卡林

左色满卡林

中文名称左色满卡林
中文同义词左色满卡林;左克罗卡林
英文名称LEVCROMAKALIM
英文同义词(3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE;(3s-trans)-yrrolidinyl);LEVCROMAKALIM;2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p;brl38227;lemakalim;levcromakelim;(3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran
CAS号94535-50-9
分子式C16H18N2O3
分子量286.33
EINECS号
相关类别
Mol文件94535-50-9.mol
结构式左色满卡林 结构式

左色满卡林 性质

熔点242-244°
比旋光度D26 -52.2° (c = 1 in chloroform)
沸点482.3±45.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
储存条件Store at RT
溶解度DMSO:可溶≤10 mM
酸度系数(pKa)13.18±0.60(Predicted)
形态固体
颜色白色至米白色

左色满卡林 用途与合成方法

Levcromakalim ((-)-Cromakalim) 是 ATP 敏感性的 K+ 通道 (KATP) 激活剂。

K + channel

Levcromakalim ((-)-Cromakalim) inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 µM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 µM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control (n=5, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 µM) to 84±1.5% of the control (n=5; P<0.05). Levcromakalim (20 and 100 µM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control (n=6 and 4, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions by LevCromakalim (100 µM) to 79±3.5% of the control (n=4; P<0.05). Tonic contraction by OXT is also suppressed by Cromakalim in a glibenclamide-sensitive manner.The function of the K ATP channels is examined with the specific channel opener LevCromakalim (Cromakalim). LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); and there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10 -4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05).

安全信息

安全说明22-24/25
WGK Germany3
RTECS号DJ2177500

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/11/08HY-14255左色满卡林
Levcromakalim
94535-50-92 mg800元
2024/11/08HY-14255左色满卡林
Levcromakalim
94535-50-95mg1200元

左色满卡林 上下游产品信息

"左色满卡林"相关产品信息
(S)-3-(1-氨基乙基)苯腈 色满卡林 N-苄基吡咯烷酮 (S)-3-二甲基氨基-3-苯丙醇 3-氨甲基-苯甲腈 左色满卡林 3-氨基-3-(3-甲基苯基)-1-丙醇 4-叔-丁氧基苯甲腈 N-甲基-3-氰基苄胺
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