洛度沙胺氨丁三醇
中文名称 | 洛度沙胺氨丁三醇 |
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中文同义词 | 洛度沙胺氨丁三醇;2-氨基-2-(羟甲基)丙烷-1,3-二醇 半(2,2'-((2-氯-5-氰基-1,3-亚苯基)双(氮烷二基))双(2-氧代乙酸盐) );2-氨基-2-(羟甲基)丙烷-1,3-二醇 半(2,2'-((2-氯-5-氰基-1,3-亚苯基)双(氮烷二基))双(2-氧代乙酸盐) );洛度沙胺杂质16 |
英文名称 | Lodoxamidetromethamine |
英文同义词 | Lodoxamidetromethamine;LodoxaMide troMethaMineon;AlMide;LodoxaMide troMetaMol;LodoxaMide troMethaMine salt;U-42585-E;Lodoxamide tromethamine (U 42585 E);2-Amino-2-(hydroxymethyl)propane-1,3-diol hemi(2,2'-((2-chloro-5-cyano-1,3-phenylene)bis(azanediyl))bis(2-oxoacetate)) |
CAS号 | 63610-09-3 |
分子式 | C15H17ClN4O9 |
分子量 | 432.77 |
EINECS号 | |
相关类别 | 医药原料药-科研原料;医药原料;原料药;医用原料;原料药及中间体;API;化学试剂 |
Mol文件 | 63610-09-3.mol |
结构式 | ![]() |
洛度沙胺氨丁三醇 性质
储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
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溶解度 | DMSO:20 mg/mL(36.11 mM 和升温) |
形态 | 固体 |
颜色 | 白色至浅黄色 |
lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45 Ca influx with associated histamine release in purified rat peritoneal mast cells.
Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-16289 | 洛度沙胺氨丁三醇 Lodoxamide tromethamine | 63610-09-3 | 5mg | 600元 |
2024/04/30 | HY-16289 | 洛度沙胺氨丁三醇 Lodoxamide tromethamine | 63610-09-3 | 10mM * 1mLin DMSO | 731元 |