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AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2

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AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Suppliers list
Company Name: Shenzhen Nexconn Pharmatechs Ltd
Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Products Intro: Product Name:Nogo-66 (1-40)
CAS:475221-20-6
Purity:98% Package:1KG;10KG;50KG
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Nogo-66 (1-40)
CAS:475221-20-6
Purity:>95% Package:1mg Remarks:BOC Sciences also provides custom synthesis services for Nogo-66 (1-40).
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
CAS:475221-20-6
Purity:99% Package:1g;7USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: CAS:475221-20-6
Purity:99% Package:5KG;1KG
Company Name: Alfa Chemistry
Tel:
Email: Info@alfa-chemistry.com
Products Intro: Product Name:L-Serinamide,n2-acetyl-L-arginyl-L-isoleucyl-L-tyrosyl-L-Lysylglycyl-L-valyl-L-isoleucyl-L-glutaminyl-L-alanyl-L-isoleucyl-L-glutaminyl-L-Lysyl-L-seryl-L-a-aspartyl-L-a-glutamylglycyl-l-histidyl-l-pro
CAS:475221-20-6
Purity:96% Remarks:https://www.alfa-chemistry.com/cas_475221-20-6.htm
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Basic information
Product Name:AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
Synonyms:ARG-ILE-TYR-LYS-GLY-VAL-ILE-GLN-ALA-ILE-GLN-LYS-SER-ASP-GLU-GLY-HIS-PRO-PHE-ARG-ALA-TYR-LEU-GLU-SER-GLU-VAL-ALA-ILE-SER-GLU-GLU-LEU-VAL-GLN-LYS-TYR-SER-ASN-SER-NH2;AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2;M.W. 4625.11 C206H324N56O65;NEP1-40;NOGO-66 (1-40);NOGO-66 (1-40) ANTAGONIST PEPTIDE;NOGO EXTRACELLULAR PEPTIDE, 1-40;PubChem ID: 90488731
CAS:475221-20-6
MF:C206H324N56O65
MW:4625.11
EINECS:
Product Categories:Various Peptides
Mol File:475221-20-6.mol
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Structure
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Chemical Properties
storage temp. -20°C
solubility H2O: 1 mg/mL
form solid
color white
Water Solubility Soluble to 1 mg/ml in water
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Usage And Synthesis
UsesNogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:
  • to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
  • to determine the effects of Nogo-A/NgR1 on autophagic activation
  • to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice

Biochem/physiol ActionsMyelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.
storageStore at -20°C
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Preparation Products And Raw materials
Tag:AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2(475221-20-6) Related Product Information
AC-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2