- berberrubine
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- $0.00 / 1KG
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2025-04-04
- CAS:15401-69-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
- Berberrubine
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- $0.00 / 20mg
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2023-02-24
- CAS:15401-69-1
- Min. Order: 5mg
- Purity: ≥90%(HPLC)
- Supply Ability: 10 g
- berberrubine
-
- $95.00 / 20mg
-
2021-11-02
- CAS:15401-69-1
- Min. Order: 20mg
- Purity: 99%
- Supply Ability: 10kg
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| | berberrubine Basic information |
| | berberrubine Chemical Properties |
| Melting point | 245℃ (DEC.) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | Off-White to Dark Yellow | | Stability: | Hygroscopic |
| | berberrubine Usage And Synthesis |
| Uses | Berberrubine Chloride is a novel alkaloid with novel nitric-oxide donating activity. Antitumor and an antimicrobial agent. | | Definition | ChEBI: Berberrubine is an alkaloid. | | in vivo | Berberrubine (oral administration; 10-20 mg/kg; 7 days) has a beneficial effect in a mouse colitis model[3]. | Animal Model: | DSS (HY-116282) treated male Balb/c mice aged 6 weeks old[3] | | Dosage: | 10 and 20 mg/kg | | Administration: | Oral administration (p.o.); 7 days | | Result: | Significantly reduced the disease activity index (DAI) with prolonged colon length and increased bodyweight at dose of 20 mg/kg.
Significantly ameliorated the DSS-induced colonic pathological alternations and decreased histological scores.
Markedly attenuated colonic inflammation by alleviating inflammatory cell infiltration and inhibiting myeloperoxidase (MPO) and cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10) productions in DSS mice.
Substantially upregulated the expression of tight junction proteins (zonula occludens-1, zonula occludens-2, claudin-1, occludin) and mRNA expression of mucins (mucin-1 and mucin-2), and decreased the Bax/Bcl-2 ratio. |
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| | berberrubine Preparation Products And Raw materials |
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