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| | LAVENDUSTIN C Basic information |
| Product Name: | LAVENDUSTIN C | | Synonyms: | 2-hydroxy-5-(2,5-dihydrobenzyl)aminobenzoic acid;Compound 5, HDBA, N-(2μ,5μ-Dihydroxybenzyl)-5-aminosalicylic acid, [2-Hydroxy-5-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoic acid;5-(2,5-Dihydroxybenzylamino)salicylic acid, N-(2,5-Dihydroxybenzyl)-5-aminosalicylic acid;5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid;5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxy-benzoic acid;NSC 666251;2-HYDROXY-5-(2,5-DIHYDROXYBENZYLAMINO)BENZOIC ACID;[2-HYDROXY-5-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOIC ACID | | CAS: | 125697-93-0 | | MF: | C14H13NO5 | | MW: | 275.26 | | EINECS: | | | Product Categories: | Other enzyme inhibitors and activators;All Inhibitors;Inhibitors;Tyrosine Kinase Inhibitors | | Mol File: | 125697-93-0.mol |  |
| | LAVENDUSTIN C Chemical Properties |
| Melting point | 193-195°C dec. | | Boiling point | 597.5±50.0 °C(Predicted) | | density | 1.551±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: soluble | | form | solid | | pka | 2.32±0.10(Predicted) | | color | Light Beige to Brown | | Stability: | Hygroscopic |
| | LAVENDUSTIN C Usage And Synthesis |
| Description | Lavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 μM. Lavendustin C also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 μM, respectively. At a concentration of 10-150 μM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation. | | Chemical Properties | Brown Solid | | Uses | Shows potent tyrosine kinase inhibitory activity. | | Definition | ChEBI: 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid is an aromatic amine. |
| | LAVENDUSTIN C Preparation Products And Raw materials |
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