1-acetyl-3,2-toluyl-5-fluorouracil
中文名称 | 1-acetyl-3,2-toluyl-5-fluorouracil |
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中文同义词 | 化合物 T10013 |
英文名称 | 1-acetyl-3,2-toluyl-5-fluorouracil |
英文同义词 | 1-acetyl-3,2-toluyl-5-fluorouracil;1-Acetyl-3-o-toluyl-5-fluorouracil;A-?OT-?Fu;2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-;1 Acetyl 3 o toluyl 5 fluorouracil,1Acetyl3otoluyl5fluorouracil |
CAS号 | 71861-76-2 |
分子式 | C14H11FN2O4 |
分子量 | 290.25 |
EINECS号 | |
相关类别 | |
Mol文件 | 71861-76-2.mol |
结构式 | ![]() |
1-acetyl-3,2-toluyl-5-fluorouracil 性质
熔点 | 141-143 °C(Solv: ethyl ether (60-29-7)) |
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沸点 | 408.8±55.0 °C(Predicted) |
密度 | 1.44±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | -5.29±0.40(Predicted) |
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).