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| | adoprazine Basic information |
| Product Name: | adoprazine | | Synonyms: | adoprazine;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Unii-7snb18Q89d;SLV 313;SLV313;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]- | | CAS: | 222551-17-9 | | MF: | C24H24FN3O2 | | MW: | 405.46 | | EINECS: | | | Product Categories: | | | Mol File: | 222551-17-9.mol |  |
| | adoprazine Chemical Properties |
| Boiling point | 565.0±50.0 °C(Predicted) | | density | 1.256 | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | | form | Powder | | pka | 6.07±0.10(Predicted) | | color | Light yellow to yellow |
| | adoprazine Usage And Synthesis |
| Biological Activity | Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties. | | in vitro | Adoprazine (SLV313) has high affinity at human recombinant D 2 , D 3 , D 4 , 5-HT < sub> 2B , and 5-HT 1A receptors, with pK i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D 2 receptor antagonist and an efficacious serotonin 5-HT 1A receptor agonist, with E max value (% effect of 10 μM 5-HT) of 73 and pK B value of 8.5 . | | in vivo | Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner. | Animal Model: | Male Wistar rats (275-350 g) | | Dosage: | 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg | | Administration: | po; single | | Result : | Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels. | | | target | | 5-HT 1A Receptor 9 (pEC 50 ) | D 2 < /sub> Receptor 9.3 (pA2) | D 3 Receptor 8.9 (pA2) | D 4 Receptor 8.0 (pKi) | 5-HT 7 Receptor 7.2 (pKi) | 5-HT 1A < /sub> Receptor 9.1 (pKi) | D 2 Receptor 8.4 (pKi) | D 3 Receptor 8.4 (pKi) | |
| | adoprazine Preparation Products And Raw materials |
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