呋喃脒二盐酸盐
| 中文名称 | 呋喃脒二盐酸盐 |
|---|---|
| 中文同义词 | 呋喃脒二盐酸盐;化合物 T27395;呋喃二脒 二盐酸盐;DB75 DIHYDROCHLORIDE; NSC 305831 DIHYDROCHLORIDE |
| 英文名称 | Furamidine dihydrochloride |
| 英文同义词 | 2,5-Furandiylbis(1,4-phenylene)bisformamidine;DB75;DB-75;Furamidine;4-[5-(4-carbamimidoylphenyl)-2-furyl]benzenecarboximidamide;WR-199385;FuraMidine Dihydrochloride;Furamidine HCl |
| CAS号 | 55368-40-6 |
| 分子式 | C18H16N4O |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 55368-40-6.mol |
| 结构式 |  |
呋喃脒二盐酸盐 性质
| 熔点 | 400-401 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 感光 |
IC50: 9.4 μM (Protein arginine methyltransferase 1 (PRMT1)); 166 µM (PRMT5), 283 µM (PRMT6) and >400 µM (PRMT4)
Parasite
Tyrosyl-DNA phosphodiesterase 1 (TDP-1)
Furamidine (compound 1; 20 μM; 72 hours; leukemia cell lines) inhibits cell growth for most of the leukemia cell lines except HEL cells which have JAK2V617F mutations.
Furamidine (compound 1; 20 μM; 15 hours; 293T cells) treatment significantly reduces the expression level of the methylated GFP-ALY protein in 293T cells.
Furamidine binds duplex DNA in the DNA minor groove selectively at AT rich sites [(A/T)4]. Furamidine can also intercalate between GC base pairs of duplex DNA. Furamidine could therefore interfere with DNA processing enzymes such as TDP-1.
Cell Viability Assay
| Cell Line: | Meg-01, K562, HL-60, NB4, MOLM13, HEL, CMK, CMY, CMS and CHRF cells |
| Concentration: | 20 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited cell growth for most of the leukemia cell lines except HEL cells which have JAK2V617F mutations. |
Western Blot Analysis
| Cell Line: | 293T cells |
| Concentration: | 20 μM |
| Incubation Time: | 15 hours |
| Result: | The expression level of the methylated GFP-ALY protein is significantly reduced. |
Furamidine (1 mg/kg; intraperitoneal injection; 3 times a week and repeated every 4 weeks; for 34 weeks; female NZB/NZW mice) and Irinotecan combined treatment suppresses proteinuria and prolongs survival of lupus-prone NZB/NZW mice. The combination treatment does not change the levels of anti-dsDNA antibodies.
| Animal Model: | Female NZB/NZW mice (6-week-old) with Irinotecan (1 mg/kg) |
| Dosage: | 1 mg/kg |
| Administration: | Intraperitoneal injection; 3 times a week and repeated every 4 weeks; for 34 weeks |
| Result: | Suppressed proteinuria and prolongs survival of lupus-prone NZB/NZW mice combined with Irinotecan. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110137 | 呋喃脒二盐酸盐 Furamidine dihydrochloride | 55368-40-6 | 5mg | 1300元 |
| 2024/04/30 | HY-110137 | Furamidine dihydrochloride | 25 mg | 4850元 |