| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Arachidonoyl Ethanolamide-d8
CAS:924894-98-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
amyjetsci
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| Tel: |
027-59626688 18771149750 |
| Email: |
sales@amyjet.com |
| Products Intro: |
Product Name:Arachidonoyl Ethanolamide-d8
Package:1mg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:Arachidonoyl Ethanolamide-d8
CAS:924894-98-4
Package:>=99% deuterated forMs (d1-d8) Remarks:390050
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| Product Name: | AEA-D8 | | Synonyms: | ARACHIDONOYL ETHANOLAMIDE-D8;ANANDAMIDE-D8;AEA-D8;N-(2-HYDROXYETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE-5,6,8,9,11,12,14,15-D8;(5Z,8Z,11Z,14Z)-5,6,8,9,11,12,14,15-octadeuterio-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide | | CAS: | 924894-98-4 | | MF: | C22H37NO2 | | MW: | 347.54 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | AEA-D8 Chemical Properties |
| solubility | 1 mg/ml EtOH:PBS pH 7.2: can dilute 1:1.6 (>380 μg/ml); 10 mg/ml EtOH:PBS pH 7.2: can dilute 1:1 (>5 mg/ml) (fro; 100 ?g/ml EtOH:PBS pH 7.2: can dilute 1:1.6 (>38 μg/ml) (; DMF: >10 mg/ml (from AEA); DMSO: >30 mg/ml (from AEA); Ethanol: >100 mg/ml (from AEA); PBS pH 7.2: <100 μg/ml (from AEA) |
| | AEA-D8 Usage And Synthesis |
| Description | Arachidonoyl ethanolamide-d8 (AEA-8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of AEA by GC- or LC-mass spectrometry. AEA is the ethanolamine amide of arachidonic acid, first isolated from porcine brain.1 It is an endogenous cannabinoid neurotransmitter that binds to both CB1 and CB2 receptors.2 AEA inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM, compared to 46 nM for Δ9-THC.1 | | Definition | ChEBI: Anandamide is an N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine. It has a role as a neurotransmitter, a vasodilator agent and a human blood serum metabolite. It is an endocannabinoid and a N-acylethanolamine 20:4. It is functionally related to an arachidonic acid. | | References | 1. Devane, W.A., Hanus, L., Breuer, A., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 258(5090),1946-1949(1992).
2. Felder, C.C., Briley, E.M., Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction Proc. Natl. Acad. Sci. USA 90(16),7656-7660(1993). |
| | AEA-D8 Preparation Products And Raw materials |
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