盐酸妥布特罗
中文名称 | 盐酸妥布特罗 |
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中文同义词 | 盐酸妥布托罗;盐酸妥布特;妥布特罗甲醇溶液标准物质;妥布特罗盐酸盐溶液,100PPM;2-叔丁氨基-1-(2-氯苯基)乙醇 盐酸盐;甲醇中妥布特罗溶液标准物质;妥布特罗盐酸盐;(+/-)-2-氯-2-[(叔丁基氨基)甲基]苯甲醇盐酸盐 |
英文名称 | Tulobuterol hydrochloride |
英文同义词 | Ventaire;Tulobuterol hydrochloride API;Tulobuterol solution;Tulobuterol Hydrochloride Solution, 100ppm;TULOBUTEROL HG;Atenos;Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-, hydrochloride (9CI);Berachin |
CAS号 | 56776-01-3 |
分子式 | C12H19Cl2NO |
分子量 | 264.19 |
EINECS号 | 634-677-4 |
相关类别 | 法医和兽医标准品;抗生素;瘦肉精类;分析标准品;日用化学品;平喘药原料药;医药原料药-科研原料;医药原料;医药原料;标准品;中药对照品;医药原料药;原料药;原料;化学试剂;Active Pharmaceutical Ingredients;API;平喘药 |
Mol文件 | 56776-01-3.mol |
结构式 | ![]() |
盐酸妥布特罗 性质
熔点 | 159-163℃ |
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储存条件 | 2-8°C |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | Soluble in methanol or water. |
敏感性 | Hygroscopic |
Merck | 14,9811 |
InChIKey | RSLNRVYIRDVHLY-UHFFFAOYSA-N |
CAS 数据库 | 56776-01-3(CAS DataBase Reference) |
β2-adrenoceptor
Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.
RT-PCR
Cell Line: | Human tracheal epithelial cells infected with RV14 |
Concentration: | 0.1 μM |
Incubation Time: | 24 hours or 72 hours |
Result: | Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection. |
In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-W011733 | Tulobuterol hydrochloride | 250 mg | 650元 | |
2024/08/19 | HY-W011733 | 盐酸妥布特罗 Tulobuterol hydrochloride | 56776-01-3 | 10mM * 1mLin DMSO | 715元 |