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| | 2-AMINO-BETA-NAPHTHOTHIAZOLE Basic information |
| Product Name: | 2-AMINO-BETA-NAPHTHOTHIAZOLE | | Synonyms: | NAPHTHO[1,2-D][1,3]THIAZOL-2-AMINE;NAPHTHO[1,2-D]THIAZOL-2-YLAMINE;2-AMINO-BETA-NAPHTHOTHIAZOLE;2-AMINO-NAPHTHO[1,2-D]THIAZOLE;2-AMINONAPHTHO-1,2-THIAZOLE;AKOS BBS-00006561;IFLAB-BB F1386-0401;LABOTEST-BB LT00154570 | | CAS: | 40172-65-4 | | MF: | C11H8N2S | | MW: | 200.26 | | EINECS: | 254-822-1 | | Product Categories: | BENZOTHIAZOLE | | Mol File: | 40172-65-4.mol |  |
| | 2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties |
| Melting point | 184-188°C | | Boiling point | 417.1±28.0 °C(Predicted) | | density | 1.403±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: ≥30mg/mL | | form | solid | | pka | 3.50±0.30(Predicted) | | color | Off-white | | Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | | CAS DataBase Reference | 40172-65-4(CAS DataBase Reference) | | EPA Substance Registry System | Naphtho[1,2-d]thiazol-2-amine (40172-65-4) |
| | 2-AMINO-BETA-NAPHTHOTHIAZOLE Usage And Synthesis |
| Description | SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3 | | Biological Activity | Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice. | | storage | +4°C | | References | Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281
Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323
Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60 |
| | 2-AMINO-BETA-NAPHTHOTHIAZOLE Preparation Products And Raw materials |
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