| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CAY10568;CAY10568,CAY-10568
CAS:22913-17-3
Purity:98% Package:500 mg
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10568
CAS:22913-17-3
Purity:98% Package:10mg;25mg;50mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:CAY10568
CAS:22913-17-3
Package:>=98% Remarks:10012565
|
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| | CAY10568 Basic information |
| Product Name: | CAY10568 | | Synonyms: | TRIMETHYL ((PHENYLCARBAMOYL)METHYL) AMMONIUM IODIDE;CAY10568;(2-anilino-2-oxoethyl)-trimethylazanium:iodide;CAY10568,CAY-10568 | | CAS: | 22913-17-3 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 22913-17-3.mol |  |
| | CAY10568 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 0.5 mg/ml | | form | A crystalline solid |
| | CAY10568 Usage And Synthesis |
| Description | Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported.1 CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact. | | References | 1. Binshtok, A.M., Bean, B.P., and Woolf, C.J. Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers Nature 449,607-610(2007). |
| | CAY10568 Preparation Products And Raw materials |
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