- GSK189254A
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- $48.00 / 1mg
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2024-11-09
- CAS:720690-73-3
- Min. Order:
- Purity: 98.71%
- Supply Ability: 10g
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| Product Name: | GSK 189254A | | Synonyms: | GSK 189254A;6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-MethylnicotinaMide;N-(4-METHOXYBENZYL)-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDIN-4-AMINE;6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide;histamine H3 receptor antagonist GS189254A;CS-2905;3-Pyridinecarboxamide, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-;Histamine Receptor,GSK-189254,GSK 189254,GSK-189254A,inhibit,GSK189254A,Inhibitor | | CAS: | 720690-73-3 | | MF: | C21H25N3O2 | | MW: | 351.44 | | EINECS: | | | Product Categories: | | | Mol File: | 720690-73-3.mol |  |
| | GSK 189254A Chemical Properties |
| Boiling point | 545.0±50.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:25.0(Max Conc. mg/mL);71.13(Max Conc. mM) | | form | A solid | | pka | 14.26±0.46(Predicted) | | color | White to off-white |
| | GSK 189254A Usage And Synthesis |
| Description | GSK189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy.It may also be useful for the treatment of dementia and neuropathic pain. Its pharmacological effect may be related to its effect on increasing the release neurotransmitter in the brain. Microdialysis studies demonstrated that GSK189254 increased the release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK189254 significantly improved performance of rats in diverse cognition paradigms, including passive avoidance, water maze, object recognition, and attentional set shift. These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders.
| | References | Medhurst, Andrew D., and A. I. J. Beresford. "GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models." Alzheimers & Dementia 321.3(2007):1032.
Plisson, Christophe, et al. "PET imaging of the CNS histamine H3 receptor using [11C] GSK189254A." Neuroimage 31.1(2006):T47-T47.
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| | GSK 189254A Preparation Products And Raw materials |
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