ABT 702 Dihydrochloride

ABT 702 Dihydrochloride Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:GSK137647A
CAS:1188890-28-9
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:ABT 702 Dihydrochloride
CAS:1188890-28-9
Purity:98% Package:50mg Remarks:BOC Sciences also provides custom synthesis services for ABT 702 Dihydrochloride.
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name:ABT-702 dihydrochloride
CAS:1188890-28-9
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:ABT-702 DIHYDROCHLORIDE
CAS:1188890-28-9
Purity:98% Package:5mg Remarks:V4402
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:ABT-702 dihydrochloride
CAS:1188890-28-9
Package:1 mg;1 mL * 10mM (in DMSO);10 mg;100 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
ABT 702 Dihydrochloride Basic information
Product Name:ABT 702 Dihydrochloride
Synonyms:ABT702 hcl;CS-2726;ABT-702;ABT702;ABT 702;5-(3-Bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride;ABT702 dihydrochloride,ABT702,ADK,Inhibitor,inhibit,ABT 702,ABT-702,Adenosine Kinase,ABT 702 dihydrochloride
CAS:1188890-28-9
MF:C22H19N6OBr.2HCl
MW:0
EINECS:
Product Categories:
Mol File:Mol File
ABT 702 Dihydrochloride Structure
ABT 702 Dihydrochloride Chemical Properties
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility insoluble in H2O; ≥107.2 mg/mL in DMSO; ≥9.84 mg/mL in EtOH with gentle warming and ultrasonic
form solid
color Orange
Safety Information
MSDS Information
ABT 702 Dihydrochloride Usage And Synthesis
Biological Activityadenosine (ado) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. inhibition of adenosine kinase (ak), the primary metabolic enzyme for ado, selectively increases ado concentrations at sites of tissue trauma and enhances the analgesic and antiinflammatory actions of ado. abt 702 is a novel, potent nonnucleoside ak inhibitor.
in vitroabt 702 was active both in inhibiting ak (ic50 ) 1.7 nm) and ado phosphorylation in the intact cells (ic50 ) 50 nm). abt 702 was also highly selective for ak inhibition as compared to other sites of ado action including ada, ado receptors, and ado transport sites [1].
in vivoabt 702 had dose-dependent antinociceptive and antiinflammatory actions in a variety of animal models of nociceptive, inflammatory, and neuropathic pain. abt 702 is the first of a novel class of potent, selective, non-nucleoside, orally active ak inhibitors that have potent antinociceptive effects in animal models [1].
IC 501.7 nm for adenosine kinase
references[1] lee ch, jiang m, cowart m, gfesser g, perner r, kim kh, gu yg, williams m, jarvis mf, kowaluk ea, stewart ao, bhagwat ss. discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. j med chem. 2001 jun 21;44(13):2133-8.
ABT 702 Dihydrochloride Preparation Products And Raw materials
Tag:ABT 702 Dihydrochloride(1188890-28-9) Related Product Information
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