N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
中文名称 | N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺 |
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中文同义词 | N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺;G9A抑制剂(UNC0646);UNC0646游离态;化合物UNC 0646;N-(1-环己基哌啶-4-基)-2-(4-异丙基-1,4-二氮杂环庚烷-1-基)-6-甲氧基-7-(3-(哌啶-1-基)丙氧基)喹唑啉-4-胺 |
英文名称 | UNC0646 |
英文同义词 | UNC0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;UNC0646/UNC-0646;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;UNC 0646;UNC0646;UNC-0646;CS-792 |
CAS号 | 1320288-17-2 |
分子式 | C36H59N7O2 |
分子量 | 621.9 |
EINECS号 | |
相关类别 | 抑制剂;细胞生物学试剂 |
Mol文件 | 1320288-17-2.mol |
结构式 |
N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺 性质
沸点 | 754.6±70.0 °C(Predicted) |
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密度 | 1.128±0.06 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,2-8°C |
溶解度 | DMSO:可溶,2mg/mL,澄清(加热) |
酸度系数(pKa) | 9.34±0.70(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
Target | Value |
G9a
(Cell-free assay) | 6 nM |
GLP
(Cell-free assay) | 15 nM |
UNC0646 (Compound 6) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC0646 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC0646 reduces H3K9me2 levels with ICW IC 50 values of 26 nM, 10 nM, 12 nM, 14 nM, 68 nM, 86 nM and 10 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53 -/- and IMR90 cell lines, respectively.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-13807 | N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺 UNC0646 | 1320288-17-2 | 5mg | 744元 |
2024/04/30 | HY-13807 | N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺 UNC0646 | 1320288-17-2 | 10mM * 1mLin DMSO | 1018元 |