ITD 1
中文名称 | ITD 1 |
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中文同义词 | 4-[1,1'-联苯]-4-基-1,4,5,6,7,8-六氢-2,7,7-三甲基-5-氧代-3-喹啉羧酸乙酯;4-([1,1'-联苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯;化合物ITD1;ITD 1 (TGF-Β RECEPTOR抑制剂);4-([1,1'-联苯]-4-基)-2,7,7-三甲基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸乙酯;ITD-1,TGF-Β信号传导的抑制剂 |
英文名称 | ITD-1 |
英文同义词 | ITD-1;4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester;AOB6123;SCHEMBL3239096;Ethyl 4-([1,1'-biphenyl]-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester;CS-1731;ITD1;ITD-1;ITD 1 |
CAS号 | 1099644-42-4 |
分子式 | C27H29NO3 |
分子量 | 415.52 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;抑制剂;Inhibitors |
Mol文件 | 1099644-42-4.mol |
结构式 |
ITD 1 性质
沸点 | 569.9±50.0 °C(Predicted) |
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密度 | 1.18±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO 中≥28.05 mg/mL;不溶于水;不溶于乙醇 |
形态 | 固体 |
酸度系数(pKa) | 1.33±0.70(Predicted) |
颜色 | 浅黄至黄色 |
Target | Value |
TGF-β
() |
ITD-1 potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. HEK293T cells are transfected with a Smad4 response element driving luciferase (SBE4-Luc) to test whether ITD-1 blocks Activin A/Nodal and/or TGFβ signaling, which utilize the same intracellular signaling cascade through Smad4. ITD-1 strongly inhibits TGFβ2 signaling with similar efficacy (92% vs. 99% respectively), but with lower potency compared to SB-431542, an ACVR1B/TGFBR1 kinase inhibitor (IC 50 = 850nM vs. 70nM respectively), and is a weak and partial inhibitor of Activin A signals. ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors .
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-12704 | ITD-1 | 1 mg | 360元 | |
2024/04/30 | S6713 | ITD 1 ITD-1 | 1099644-42-4 | 5mg | 795.37元 |