TPI1;TPI 1
| 中文名称 | TPI1;TPI 1 |
|---|---|
| 中文同义词 | TPI-1游离态;2',5'-二氯-[1,1'-联苯基]-2,5-二酮;化合物TPI1;2',5'-二氯-[1,1'-联苯基]-2,5-二酮 |
| 英文名称 | 2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione |
| 英文同义词 | TPI-1;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;TPI1;TPI 1;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;Recombinant Human TIM/TPI1 Protein, His Tag;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;TPI-1,Inhibitor,inhibit,Phosphatase;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione |
| CAS号 | 79756-69-7 |
| 分子式 | C12H6Cl2O2 |
| 分子量 | 253.08 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 79756-69-7.mol |
| 结构式 |  |
TPI1;TPI 1 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：1mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至黄色 |
| Target | Value |
|
SHP-1
(Cell-free assay) | 40 nM |
SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ + cells and induces IFNγ + cells in human peripheral blood.
TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ + cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.
安全信息
| 海关编码 | 2914698090 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100463 | TPI-1 | 1 mg | 545元 | |
| 2024/04/30 | HY-100463 | TPI1;TPI 1 TPI-1 | 79756-69-7 | 5mg | 1200元 |