3-脱氧葡萄糖醛酮
中文名称 | 3-脱氧葡萄糖醛酮 |
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中文同义词 | 3-脱氧-D-葡糖醛酮;3-葡萄糖醛酮;3-脱氧-D-葡萄糖酮醛;3-脱氧葡萄糖醇;3-脱氧葡萄糖;3-脱氧葡萄糖醛酮;3-脱氧葡萄糖酮;化合物 T19117 |
英文名称 | 3-DEOXYGLUCOSONE |
英文同义词 | 3-deoxy-d-erythro-hexos-2-ulose;3-deoxy-d-erythro-hexosulos;d-3-deoxyglucosone;3DG;3-DEOXY-D-ERYTHRO-HEXULOSE2-KETO-3-DEOXYGLUCOSE;3-DEOXYGLUCOSONE;3-Deoxy-D-arabino-2-hexosulose;3-Deoxy-D-erythro-2-hexosulose |
CAS号 | 4084-27-9 |
分子式 | C6H10O5 |
分子量 | 162.14 |
EINECS号 | |
相关类别 | 13C & 2H Sugars;aldehydes;Carbohydrates & Derivatives;Intermediates |
Mol文件 | 4084-27-9.mol |
结构式 | ![]() |
3-脱氧葡萄糖醛酮 性质
熔点 | 73-75°C |
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沸点 | 208.81°C (rough estimate) |
密度 | 1.2132 (rough estimate) |
折射率 | 1.4230 (estimate) |
RTECS号 | MQ3390000 |
储存条件 | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
溶解度 | 可溶于甲醇(轻微)、水(轻微、超声处理) |
形态 | 固体 |
酸度系数(pKa) | 13.17±0.20(Predicted) |
颜色 | 粘黄色 |
水溶解性 | Soluble in water, methanol or hot ethanol. |
稳定性 | 吸湿性 |
3-Deoxyglucosone (80 ng/ml-1000 ng/ml; 1 hour) markedly increases GLP-1 secretion by 1.23-folds in 300 ng/ml or 1000 ng/ml 3DG-treated group. But at alower concentration (80 ng/ml) has no effects.3-Deoxyglucosone (300 ng/ml; 1 hour) dramatically increases intracellular Ca 2+ levels by Fluo-3/AM determination (2.5 μM for 30 mins). But 3DG does not affect intracellular cAMP levels in a cAMP Elisa assay.3-Deoxyglucosone (300 ng/ml; 1 hour) significantly increases the protein expression levels of TAS1R2, TAS1R3, and TRPM5 under both glucose-free and highconditions.
Western Blot Analysis
Cell Line: | STC-1 cells |
Concentration: | 300 ng/ml |
Incubation Time: | 1 hour |
Result: | Upregulated TAS1R2, TAS1R3, and TRPM5 expression. |
3-Deoxyglucosone (intragastric administration; 20 mg/kg; single dose) impairs glucose tolerance with increased AUC, but the plasma glucagon levels are not significantly different. It developes impaired glucose regulation (IGR) with obviously pancreatic islet cell dysfunction in kunming mice and SD-rats.3-deoxyglucosone (gastric gavage; 5-50 mg/kg; once daily; 2 weeks) is significantly increased in the upper small intestine (1.4-fold), lower small intestine (1.4-fold), ileum (1.4-fold) and colon (two fold) compared with the basal levels in the corresponding control group. In addition, the protein expressions of TAS1R2, TAS1R3 and TRPM5 in both duodenum and colon are significantly decreased.
Animal Model: | SD rats |
Dosage: | 5, 20 and 50 mg/kg |
Administration: | oral administration; once daily; 2 weeks |
Result: | Was capable of accumulating in intestinal tissue and thereby decreased secretion of GLP-1 and insulin. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N7426 | 3-Deoxyglucosone | 1 mg | 2320元 | |
2024/08/19 | HY-N7426 | 3-脱氧葡萄糖醛酮 3-Deoxyglucosone | 4084-27-9 | 5 mg | 5800元 |