- (E/Z)-SIB-1893
-
- $67.00 / 5mg
-
2024-11-19
- CAS:6266-99-5
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
|
| | SIB 1893 Basic information |
| Product Name: | SIB 1893 | | Synonyms: | SIB 1893;2-METHYL-6-(2-PHENYLETHENYL)PYRIDINE;(E)-2-METHYL-6-(2-PHENYLETHYL)-PYRIDINE;(E)-2-METHYL-6-STYRYL-PYRIDINE;2-Methyl-6-[(E)-2-phenylethenyl]pyridine;NSC 36665;Pyridine, 2-methyl-6-(2-phenylethenyl)-;(E/Z)-SIB-1893 | | CAS: | 6266-99-5 | | MF: | C14H13N | | MW: | 195.26 | | EINECS: | | | Product Categories: | Glutamate receptor | | Mol File: | 6266-99-5.mol |  |
| | SIB 1893 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: 18 mg/mL | | form | solid | | color | White to off-white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | SIB 1893 Usage And Synthesis |
| Uses | SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2). | | Definition | ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes. | | Biological Activity | A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors. |
| | SIB 1893 Preparation Products And Raw materials |
|