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Shaanxi Dideu Medichem Co. Ltd
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029-61856359 18690052321 |
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1027@dideu.com |
| Products Intro: |
Product Name:PHENYRAMIDOL
CAS:553-69-5
Purity:99% Package:25千克/桶/
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guoyungurui
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18162595016 |
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Product Name:Macitentan Impurity 49
CAS:553-69-5
Purity:95%+HPLC Package:10mg;25mg;50mg;100mg;200mg
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| Company Name: |
CLEARSYNTH LABS LTD.
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+91-22-45045900 |
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sales@clearsynth.com |
| Products Intro: |
Product Name:(±)-Phenyramidol
CAS:553-69-5
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| | PHENYRAMIDOL Basic information |
| Product Name: | PHENYRAMIDOL | | Synonyms: | 1-Phenyl-2-(2-pyridinylamino)ethanol;2-(beta-Hydroxyphenethylamino)Pyridine;α-[(2-Pyridylamino)methyl]benzyl alcohol;1-phenyl-2-(2-pyridylamino)ethanol;1-phenyl-2-(pyridin-2-ylamino)ethanol;Abbolexin;alpha-[(2-Pyridylamino)methyl]benzyl alcohol;Analexin | | CAS: | 553-69-5 | | MF: | C13H14N2O | | MW: | 214.26 | | EINECS: | 209-044-7 | | Product Categories: | | | Mol File: | 553-69-5.mol |  |
| | PHENYRAMIDOL Chemical Properties |
| Melting point | 82-85° | | Boiling point | 354.4°C (rough estimate) | | density | 1.0850 (rough estimate) | | refractive index | 1.6450 (estimate) | | pka | 5.85(at 25℃) | | EPA Substance Registry System | Fenyramidol (553-69-5) |
| Toxicity | LD50 oral in rat: 756mg/kg |
| | PHENYRAMIDOL Usage And Synthesis |
| Originator | Analexin, Mallinckrodt Inc., US ,1960 | | Uses | Analgesic; relaxant
(skeletal muscle). | | Uses | (±)-Phenyramidol can be used in biological study of preparation of nitric oxide releasing prodrugs useful in the treatment of diseases. It is also a muscle relaxant drug. | | Definition | ChEBI: Fenyramidol is an aminopyridine. | | Manufacturing Process | A mixture containing 188 g (0.20 mol) of 2-arninopyridine, 0.55 g of lithium amide and 75 cc of anhydrous toluene was refluxed for 1.5 hours. Styrene oxide (12.0 g = 0.10 mol) was then added to the reaction mixture with stirring over a period of ten minutes. The reaction mixture was stirred and refluxed for an additional 3.5 hours. A crystalline precipitate was formed during the reaction which was removed by filtration, MP 170°C to 171°C. 1.5 g. The filtrate was concentrated to dryness and a dark residue remained which was crystallized from anhydrous ether; yield 6.0 g. Upon recrystallization of the crude solid from 30 cc of isopropyl alcohol, 2.0 g of a light yellow solid was isolated; MP 170° to 171°C. | | Therapeutic Function | Analgesic, Muscle relaxant | | Synthesis Reference(s) | Journal of the American Chemical Society, 81, p. 4351, 1959 DOI: 10.1021/ja01525a062 | | General Description | Crystals (from dilute methanol). | | Reactivity Profile | PHENYRAMIDOL is an amine and an alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. | | Fire Hazard | Flash point data for PHENYRAMIDOL are not available. PHENYRAMIDOL is probably combustible. |
| | PHENYRAMIDOL Preparation Products And Raw materials |
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