2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸
中文名称 | 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸 |
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中文同义词 | 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸;2-[[4-[2-[[(环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫代]-2-甲基丙酸;GW7647 CALBIOCHEM;2-((4-(2-(3-环己基-1-(4-环己基丁基)脲基)乙基)苯基)硫基)-2-甲基丙酸 |
英文名称 | GW7647 |
英文同义词 | 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropa;GW7647, >=98%;Propanoic acid, 2-[[4-[2-[[(cyclohexylaMino)carbonyl](4-cyclohexylbutyl)aMino]ethyl]phenyl]thio]-2-Methyl-;GWalpha 7647;GW 7647X;2-((4-(2-(((Cyclohexylamino)carbonyl)-(4-cyclohexylbutyl)amino)ethyl)phenyl)thio)-2-methylpropanoicacid;2-[[4-[2-[[(CYCLOHEXYLAMINO)CARBONYL](4-CYCLOHEXYLBUTYL)AMINO]ETHYL]PHENYL]THIO]-2-METHYLPROPANOIC ACID;2-(4-(2-(1-CYCLOHEXANEBUTYL)-3-CYCLOHEXYLUREIDO)ETHYL)PHENYLTHIO)-2-METHYLPROPIONIC ACID |
CAS号 | 265129-71-3 |
分子式 | C29H46N2O3S |
分子量 | 502.75 |
EINECS号 | |
相关类别 | 抗体-二抗;Intracellular receptor |
Mol文件 | 265129-71-3.mol |
结构式 |
2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸 性质
熔点 | 156 - 157°C |
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沸点 | 693.9±55.0 °C(Predicted) |
密度 | 1.12 |
储存条件 | Store at RT |
溶解度 | DMSO:16 mg/mL,可溶 |
形态 | 白色固体 |
酸度系数(pKa) | 3.79±0.10(Predicted) |
颜色 | 白色 |
InChIKey | PKNYXWMTHFMHKD-UHFFFAOYSA-N |
PPARα 6 nM (EC 50 , Human PPARα) |
PPARγ 1.1 μM (EC 50 , Human PPARγ) |
PPARδ 6.2 μM (EC 50 , Human PPARδ) |
GW7647 (1 μM) causes a significant increase of PDZK1 protein expression to 129.7 ± 6.5% of vehicle treated control in Caco2BBE cells in the absence and presence of IL-1β. GW7647 also attenuates the IL-1β-mediated decrease in PDZK1 expression. GW7647 (50 nM) stimulates the PI3K phosphorylation followed by the Akt (Ser473) phosphorylation, which induces NOS1 phosphorylation increased the amounts of NO released in the stripped antral mucosa. GW7647 (50 nM) enhances the initial phase of Ca 2+ -regulated exocytotic events stimulated by ACh in antral mucous cells, but GW7647 alone does not evoke any exocytotic event. GW7647 plus ACh stimulates the effects of wortmannin (50 nM) and AKT-inh (100 nM) on the exocytotic events in antral mucous cells. GW 7647 (100 nM) reduces the AQP9 protein abundance by 43%, but it shows not significant effect at 10 and 1,000 nM in WIF-B9 hepatocytes. GW 7647 (100 nM) causes a 24% reduction in AQP9 protein abundance in HepG2 cells, however, it does not significantly increase the protein abundance of L-FABP in HepG2 hepatocytes.
GW7647 (3 mg/kg per day) does not prevent the development of cardiac hypertrophy, but it prevents the decline in left ventricular ejection fraction in vivo.
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-13861 | 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸 GW7647 | 265129-71-3 | 5mg | 1200元 |
2024/04/30 | HY-13861 | 2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸 GW7647 | 265129-71-3 | 10mM * 1mLin DMSO | 1327元 |