TYRPHOSTIN AG 555
| 中文名称 | TYRPHOSTIN AG 555 |
|---|---|
| 中文同义词 | (E)-2-氰基-3-(3,4-二羟基苯基)-N-(3-苯基丙基)丙烯酰胺;化合物AG 555;AG 555(TYRPHOSTIN B46),抑制剂 |
| 英文名称 | TYRPHOSTIN B46 |
| 英文同义词 | N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE;N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE;TYRPHOSTIN AG 555;TYRPHOSTIN B46;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE;AG 555;ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE;Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide |
| CAS号 | 133550-34-2 |
| 分子式 | C19H18N2O3 |
| 分子量 | 322.36 |
| EINECS号 | |
| 相关类别 | Protein Kinase;Intracellular Signaling |
| Mol文件 | 133550-34-2.mol |
| 结构式 |  |
TYRPHOSTIN AG 555 性质
| 沸点 | 621.1±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.273±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于DMSO或乙醇：可溶 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 8.82±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
AG-555 (Tyrphostin B46)是酪氨酸激酶抑制剂，可与拓扑异构酶I直接相互作用，因而阻止DNA松弛。它抑制EGFR，IC50为0.7 μM。
| Target | Value |
|
EGFR
(Cell-free assay) | 0.7 μM |
AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle.
Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells.
Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence.
Cell Proliferation Assay
| Cell Line: | NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. |
| Concentration: | 100 μM. |
| Incubation Time: | 1 hour. |
| Result: | Inhibited Mo-MuLV proviral DNA integration. |
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-15336 | AG 555 | 5 mg | 500元 | |
| 2024/08/19 | HY-15336 | TYRPHOSTIN AG 555 AG 555 | 133550-34-2 | 10mM * 1mLin DMSO | 550元 |