HOECHST 34580
中文名称 | HOECHST 34580 |
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中文同义词 | 赫斯特34580游离;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺;化合物HOECHST 34580;NO34580 荧光染料;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺 |
英文名称 | HOECHST 34580 |
英文同义词 | HOECHST 34580;HOE 34580;ProaMine;2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;Hoechst 34580 (HOE 34580);N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline |
CAS号 | 23555-00-2 |
分子式 | C27H29N7 |
分子量 | 451.57 |
EINECS号 | |
相关类别 | Benzimidazole |
Mol文件 | 23555-00-2.mol |
结构式 |
HOECHST 34580 性质
熔点 | >300℃ |
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沸点 | 733.2±70.0 °C(Predicted) |
密度 | 1.280±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C(protect from light) |
溶解度 | 溶于二甲亚砜、水 |
形态 | 粉末 |
酸度系数(pKa) | 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃) |
颜色 | 黄色到绿色 |
最大波长(λmax) | 392nm |
生物领域应用 | Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing |
Target | Value |
Aβ
(Cell-free assay) | 0.86 μM |
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S0486 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 5mg | 2047.06元 |
2024/08/19 | S0486 | HOECHST 34580 Hoechst 34580 | 23555-00-2 | 25mg | 6445.63元 |