GABAPENTIN-D6 HYDROCHLORIDE manufacturers
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| | GABAPENTIN-D6 HYDROCHLORIDE Basic information |
| Product Name: | GABAPENTIN-D6 HYDROCHLORIDE | | Synonyms: | GABAPENTIN-D6 HYDROCHLORIDE;1-(aminomethyl)cyclohexaneacetic acid hydrochloride;Neurontin hydrochloride;Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride (1:1);Neurontin HCl;1-(Amino Methyl) Cyclohexane Acetic Acid Hydrochloride
Hemihydrate Salt;GABAPENTIN-D6 HYDROCHLORIDE USP/EP/BP;Gabapentin HCl (Neurontin) | | CAS: | 60142-95-2 | | MF: | C9H12ClD6NO2 | | MW: | 213.73 | | EINECS: | 262-075-8 | | Product Categories: | Inhibitors | | Mol File: | Mol File |  |
| | GABAPENTIN-D6 HYDROCHLORIDE Chemical Properties |
| Melting point | 148-151℃ (ethanol ) | | density | 0.001g/cm3 at 20℃ | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | LogP | -1.33--1.17 at pH4-9 | | Surface tension | 63.69mN/m at 1g/L and 20℃ |
| | GABAPENTIN-D6 HYDROCHLORIDE Usage And Synthesis |
| Uses | Gabapentin Hydrochloride is a salt analogue of Gabapentin-d6 (G117253), a labelled amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant. | | Biological Activity | gabapentin (neurontin) is a pharmaceutical drug, specifically a gaba analog. it was originally developed to treatepilepsy, and currently is also used to relieve neuropathic pain. | | in vivo | Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) hydrochloride has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks[2].
Gabapentin (1-100 mg/kg; i.p.; once; male mice) hydrochloride has analgesic effect and reduces writhing in a dose-dependent manner[3].
| Animal Model: | Male BALB/c mice (35-45 g)[2] | | Dosage: | 5 and 10 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Increased the time spent in target quadrant and decreased the distance to platform in MWM test
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Decreased the transfer latency on second day in mEPM test
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Prolonged retention latency in PA test
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| Animal Model: | Male mice (26-30 g)[3] | | Dosage: | 1, 5, 10, 50 and 100 mg/kg | | Administration: | Intraperitoneal injection; once | | Result: | Produced 45-70% inhibition of writhing. |
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| | GABAPENTIN-D6 HYDROCHLORIDE Preparation Products And Raw materials |
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