F16 manufacturers
- F16
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- $30.00 / 5mg
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2024-11-19
- CAS:36098-33-6
- Min. Order:
- Purity: 99.66%
- Supply Ability: 10g
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| Product Name: | F16 | | Synonyms: | F16;4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE;4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;F-16;COMPOUND F16;Compound F16);F16
(F-16;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;F16/Cell proliferation inhibitor (F16) | | CAS: | 36098-33-6 | | MF: | C16H15IN2 | | MW: | 362.21 | | EINECS: | | | Product Categories: | | | Mol File: | 36098-33-6.mol |  |
| storage temp. | Store at -20°C | | solubility | ≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide | | form | Orange solid. | | color | Yellow to orange |
| Uses | F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines. | | Biological Activity | f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2]. | | references | [1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336. |
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