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Product Name:6,7-Dimethyltetrahydropterin hydrochloride
CAS:167423-51-0
Purity:99% Package:1G;10G;100G
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Product Name:6,7-Dimethyltetrahydropterin hydrochloride
CAS:167423-51-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE
CAS:167423-51-0
Purity:98% Package:500mg; 50mg; 100mg Remarks:Medbio
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Product Name:6,7-Dimethyltetrahydropterin (hydrochloride)
CAS:167423-51-0
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| | 6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Basic information |
| | 6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in H2O | | form | crystalline solid |
| | 6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Usage And Synthesis |
| Biological Activity | 6,7-dimethyltetrahydropterin is a gtp cyclohydrolase i inhibitor.gtp cyclohydrolase i catalyzes the formation of d-erythro-7,8-dihydroneopterin (dihydroneopterin) triphosphate and formate from gtp. dihydroneopterin triphosphate has been identified as a critical intermediate in the biosynthesis of folic acid, pteridines in insects and amphibians, and tetrahydrobiopterin. tetrahydrobiopterin is the obligatory cofactor for tyrosine and tryptophan hydroxylase, which are rate-limiting enzymes for biogenic amine synthesis. tetrahydrobiopterin is the cofactor for phenylalanine hydroxylase as well, which converts lphenylalanine to l-tyrosine. | | in vitro | previous study identified 6,7-dimethyltetrahydropterin as a noncompetitive inhibitor of gtp cyclohydrolase. however, no substrate inhibition of the enzyme was detected 1mm gtp, which is about 8-fold the km value of the enzyme [1]. another study found that phenylalanine hydroxylase could be inhibited by 6,7-dimethyltetrahydropterin, its cofactor. the rate of inactivation, which was irreversible, increased with the concentration of 6,7-dimethyltetrahydropterin. moreover, 6,7-dimethyltetrahydropterin was found to be unstable when the solution was exposed to air but was stabilized by dithiothreitol the aerobic oxidation of which was significantly accelerated by 6,7-dimethyltetrahydropterin [2]. | | IC 50 | 76-112 μm for gtp cyclohydrolase i | | references | [1] shen, r. ,alam, a. and zhang, y. inhibition of gtp cyclohydrolase i by pterins. biochimica et biophysica acta 965, 9-15 (1988).
[2] jakubovic a, woolf li, chan-henry e. the inactivation of phenylalanine hydroxylase by 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine and the aerobic oxidation of the latter. the effects of catalase, dithiothreitol and reduced nicotinamide-adenine dinucleotide. biochem j. 1971 nov;125(2):563-8. |
| | 6,7-DIMETHYLTETRAHYDROPTERIN HYDROCHLORIDE Preparation Products And Raw materials |
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