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| | A 71623 Basic information |
| Product Name: | A 71623 | | Synonyms: | N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-TRYPTOPHYL-N6-[[(2-METHYLPHENYL)AMINO]CARBONYL]-L-LYSYL-L-ALPHA-ASPARTYL-NA-METHYL-L-PHENYLALANINAMIDE;N-Boc-L-Trp-[(2S)-2-Amino*-6-[3-(2-methylphenyl)ureido]hexanoyl]-L-Asp-N-methyl-L-Phe-NH2;N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide;A 71623;L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-;A-71623 TFA | | CAS: | 130408-77-4 | | MF: | C44H56N8O9 | | MW: | 840.96 | | EINECS: | | | Product Categories: | | | Mol File: | 130408-77-4.mol |  |
| | A 71623 Chemical Properties |
| storage temp. | Desiccate at -20°C | | solubility | Soluble to 1 mg/ml in 20mM PBS buffer | | form | solid | | color | White |
| | A 71623 Usage And Synthesis |
| Uses | A-71623 is a potent CCK agonist with 1200-fold selectivity over the CCK2 receptor. | | Biological Activity | Potent CCK 1 agonist (IC 50 = 3.7 nM) with 1200-fold selectivity over the CCK 2 receptor. Suppresses food intake following central or peripheral administration. | | storage | Store at -20°C | | references | [1]. gracey dj, bell r, king dj. differential effects of the ccka receptor ligands pd-140,548 and a-71623 on latent inhibition in the rat. progress in neuro-psychopharmacology and biological psychiatry, 2002, 26(3): 497-504.
[2]. lin cw, shiosaki k, miller tr, et al. characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, a-71623 and a-70874, that exhibit high potency and selectivity for cholecystokinin-a receptors. molecular pharmacology, 1991, 39(3): 346-351.
[3]. kaufmann r, lindschau c, scho t, et al. type b cholecystokinin receptors on rat glioma c6 cells. binding studies and measurement of intracellular calcium mobilization. brain research, 1994, 639(1): 109-114. |
| | A 71623 Preparation Products And Raw materials |
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