| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:LY 379268
CAS:191471-52-0
Package:10Mg,50Mg,5Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:LY 379268;(1R,4R,5S,6R)-4-AMino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid
CAS:191471-52-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Ascent Scientific
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| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
| Products Intro: |
Product Name:LY 379268
CAS:191471-52-0
Purity:>99% Package:10mg;50mg Remarks:Group II mGlu agonist. Systemically active.
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| | LY 379268 Basic information |
| Product Name: | LY 379268 | | Synonyms: | LY 379268;2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-;(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid;LY397268;CS-1087 | | CAS: | 191471-52-0 | | MF: | C7H9NO5 | | MW: | 187.15 | | EINECS: | | | Product Categories: | AMINOACID;Glutamate | | Mol File: | 191471-52-0.mol |  |
| | LY 379268 Chemical Properties |
| Boiling point | 413.9±45.0 °C(Predicted) | | density | 1.716±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | Soluble in H2O or NaOH | | form | solid | | pka | 1.81±0.40(Predicted) | | color | White | | Water Solubility | Soluble to 20 mM in water and to 100 mM in 1eq. NaOH |
| | LY 379268 Usage And Synthesis |
| Uses | LY 379268 is a group II metabotropic glutamate receptors (mGlu2/3) receptor agonist (1,2). Studies have shown that LY379268 significantly attenuated cocaine-induced increases in DA in nonhuman primates. | | Definition | ChEBI: LY 379268 is an organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. It has a role as a metabotropic glutamate receptor agonist, a neuroprotective agent, an antipsychotic agent and an anxiolytic drug. It is an organic heterobicyclic compound, a bridged compound and an amino dicarboxylic acid. | | Biological Activity | Highly selective group II mGlu receptor agonist (EC 50 values are 2.69 and 4.48 nM for hmGlu 2 and hmGlu 3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. | | storage | Store at +4°C |
| | LY 379268 Preparation Products And Raw materials |
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