(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸
中文名称 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 |
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中文同义词 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸;(1S,2S,5R,6S)-2-氨基双环[3.1.0]己烷-2,6-二羧酸;EGLUMETAD|||LY354740 |
英文名称 | Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) |
英文同义词 | Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI);Eglumegad;Eglumetad;LY 354740;(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid;Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S... |
CAS号 | 176199-48-7 |
分子式 | C8H11NO4 |
分子量 | 185.18 |
EINECS号 | |
相关类别 | CYCLOPENTANE;Glutamate |
Mol文件 | 176199-48-7.mol |
结构式 |
(1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 性质
熔点 | 270-271 °C |
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沸点 | 376.4±32.0 °C(Predicted) |
密度 | 1.569 |
储存条件 | Keep in dark place,Sealed in dry,2-8°C |
溶解度 | H2O:6.33 mg/mL(34.18 mM;需要超声波和加热) |
形态 | 粉末 |
酸度系数(pKa) | 2.06±0.40(Predicted) |
颜色 | 白色至米白色 |
mGluR2R 5 nM (IC 50 ) |
mGluR3R 24 nM (IC 50 ) |
Eglumegad (LY354740) down-regulates spots 1014, 1822 (hypoxia up-regulated protein 1), 4513 (an isoform of protein disulfide isomerase 3), 6204, 6312, 7306 (26S proteasome non-ATPase regulatory subunit 7) and protein spots 1013 and 6005 (destrin), and up-regulates spot 6507 (collapsin response mediator protein 1) in mouse cortical neurons.
Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1 −/− or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1 −/− and WT mice at concentration of 30 mg/kg. Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) reduces spontaneous locomotor activity in wild-type and Gria1 −/− mice. Eglumegad (LY354740) (15 mg/kg, i.p.) dreases novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females. Eglumegad (LY354740) (15 mg/kg, i.p.) significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in of females. Eglumegad (LY354740) (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-18941 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad | 176199-48-7 | 5mg | 1500元 |
2024/04/30 | HY-18941 | (1S,2S,5R,6S)-2-氨基二环[3.1.0]己烷-2,6-二羧酸 Eglumegad | 176199-48-7 | 10mM * 1mLin Water | 1650元 |