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Lynnchem
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Product Name:Apoptolidin
CAS:194874-06-1
Purity:>95% by HPLC Package:0.1mg;0.5mg
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| | Apoptolidin Basic information |
| Product Name: | Apoptolidin | | Synonyms: | Apoptolidin;Apoptolidin A Ready Made Solution;FU 40A;L-glycero-α-D-galacto-2-Nonulopyranose, O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentam... | | CAS: | 194874-06-1 | | MF: | C58H96O21 | | MW: | 1129.38 | | EINECS: | 200-664-3 | | Product Categories: | | | Mol File: | 194874-06-1.mol |  |
| | Apoptolidin Chemical Properties |
| Melting point | 128-130° | | alpha | 21D -5.2° (c = 1.0 in methanol) | | Boiling point | 1108.9±65.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | Fp | 87℃ | | storage temp. | -20°C | | solubility | Soluble in DMSO, DMF, ethanol, or methanol. | | pka | 11.71±0.70(Predicted) | | form | DMSO solution | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months. |
| RIDADR | NA 1993 / PGIII | | WGK Germany | 2 |
| | Apoptolidin Usage And Synthesis |
| Description | Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1?Is believed to act via inhibition of F0F1-ATPase2?but correlation studies indicate that a second mechanism may be the actual mode of action3.? Cell permeable. | | Uses | Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action. | | References | 1) Kim et al. (1997), Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.; J. Antibiot. (Tokyo), 50 628
2) Salomon et al. (2001), Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase; Chem. Biol., 8 71
3) Wender et al. (2006), Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues; Org. Lett., 8 589 |
| | Apoptolidin Preparation Products And Raw materials |
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