- 3-Bromo-4-hydroxypyridine
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- $15.00 / 1KG
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2021-07-13
- CAS:36953-41-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 3-Bromo-4-hydroxypyridine Basic information |
| Product Name: | 3-Bromo-4-hydroxypyridine | | Synonyms: | 3-BROMO-4-HYDROXYPYRIDINE;3-BROMO-4-PYRIDINOL;4-HYDROXY-3-BROMOPYRIDINE;3-BROMO-4-HYDROXYPYRIDINE 97%;Synthesis of 3-bromopyridin-4-ol;4-Pyridinol, 3-bromo-;3-Bromo-4-hydroxypyridine,97%;3-Bromo-4-hydroxypyridine ISO 9001：2015 REACH | | CAS: | 36953-41-0 | | MF: | C5H4BrNO | | MW: | 174 | | EINECS: | | | Product Categories: | Pyridine;Pyridines | | Mol File: | 36953-41-0.mol |  |
| | 3-Bromo-4-hydroxypyridine Chemical Properties |
| Melting point | 225-230℃ | | Boiling point | 338.2±22.0 °C(Predicted) | | density | 1.788±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | form | powder | | pka | 3.71±0.18(Predicted) | | color | light yellow | | CAS DataBase Reference | 36953-41-0(CAS DataBase Reference) |
| | 3-Bromo-4-hydroxypyridine Usage And Synthesis |
| Uses | 3-Bromo-4-hydroxypyridine is a pyrrole that can be used in cancer treatment. It inhibits the growth of cancer cells by binding to MKN-45 on the cell surface, thereby preventing it from binding to other proteins and triggering cell proliferation. | | Synthesis |
3-Bromo-4-hydroxypyridine is synthesized from 3-bromo-5 hydroxypyridine by reacting it with ammonia or methylamine.
Concentrated sulfuric acid (85.0mL) and the 3-bromo-4-aminopyridine (113.0g, 0.65mol) were added successively to the distilled water (550.0mL) at 0°C, and then NaNO2 (63.1g, 0.91mol) aqueous solution (130.0mL) was added drop-wise to maintain the temperature between 0 and 5°C. After stirring at r. t. for 1h, the reaction mixture was heated at 95°C for a further 0.5h. Upon cooling to below 0°C, the mixture was alkalized to pH 6 with saturated sodium hydroxide solution, washed with ethyl acetate (200mL×3) and brine (200mL), dried over anhydrous Na2SO4, filtered and concentrated to yield 3-Bromo-4-hydroxypyridine as a yellow solid (75.1g, 66.2percent).
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| | 3-Bromo-4-hydroxypyridine Preparation Products And Raw materials |
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