- Tolimidone
-
- $0.10 / 1KG
-
2020-04-25
- CAS:41964-07-2
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 1000 tons
- Tolimidone
-
- $1.00 / 1KG
-
2020-02-26
- CAS: 41964-07-2
- Min. Order: 1KG
- Purity: 99%+
- Supply Ability: 100 tons
- Tolimidone
-
- $0.00 / 1Kg
-
2020-02-26
- CAS: 41964-07-2
- Min. Order: 1KG
- Purity: 99.0%+
- Supply Ability: 100 tons
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| | Tolimidone Basic information |
| Product Name: | Tolimidone | | Synonyms: | 2(1H)-Pyrimidinone, 5-(3-methylphenoxy)-;5-(3-methylphenoxy)-1H-pyrimidin-2-one;5-(3-Methylphenoxy)-2(1H)-pyrimidinone;NSC 314335;CID-39065;Tolimidone;5-(m-Tolyloxy)pyrimidin-2(1H)-one;CP-26154 | | CAS: | 41964-07-2 | | MF: | C11H10N2O2 | | MW: | 202.21 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 41964-07-2.mol |  |
| | Tolimidone Chemical Properties |
| Melting point | 163-164℃ | | density | 1.22 | | storage temp. | room temp | | solubility | DMSO: soluble15mg/mL (clear solution) | | form | powder | | pka | 8.14±0.10(Predicted) | | color | white to beige |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 |
| | Tolimidone Usage And Synthesis |
| Description | MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM). It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test. This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity. MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain. | | Uses | Tolimidone (MLR-1023) is an allosteric Lyn kinase activator that has been shown to reduce blood glucose levels in mice. Studies show that Tolimidone is an effective insulin receptor-potentiating agent that is potentially capable of producing durable blood glucose-lowering activity in diabetics. Tolimidone is a candidate for the treatment of type 2 diabetes. | | storage | Store at +4°C |
| | Tolimidone Preparation Products And Raw materials |
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