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| | Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Basic information |
| Product Name: | Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride | | Synonyms: | Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride;CK-1752A, N-[2-(Diethylamino)ethyl]-4μ-[(methylsulfonyl)amino]benzamide monohydrate monohydrochloride;Sematilide monohydrate monohydrochloride;Ck 1752a;N-(2-(Diethylamino)ethyl)-4-((methylsulfonyl)amino)benzamide monohydrochloride;Sematilide HCl;Sematilide hydrochloride;Sematilide monohydrochloride | | CAS: | 101526-62-9 | | MF: | C14H23N3O3SHClH2O | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | 101526-62-9.mol |  |
| | Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Chemical Properties |
| Melting point | 141-142° (Lumma); mp 137° and mp 142° (Argentieri) | | storage temp. | 2-8°C | | solubility | H2O: ≥16mg/mL | | pka | pKa1 7.60; pKa2 9.51(at 25℃) | | form | powder | | color | white to beige |
| WGK Germany | 3 | | Toxicity | LD50 i.p. in mice: 250-300 mg/kg (Lumma); LD50 in mice, rats, dogs (mg/kg): 96, 92, 143-175 i.v.; 1,800, 3,200, 500-1,000 orally (Argentieri) |
| | Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Usage And Synthesis |
| Uses | Sematilide, also known as CK-1752, is a class III antiarrhythmic. It is a selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness. | | Uses | Cardiac depressant (anti-arrhythmic). |
| | Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monoh ydrochloride Preparation Products And Raw materials |
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