ChemicalBook > Product Catalog >API >Respiratory Drugs >Antitussives >Dextromethorphan hydrobromide monohydrate

Dextromethorphan hydrobromide monohydrate

Dextromethorphan hydrobromide monohydrate Basic information
Product Name:Dextromethorphan hydrobromide monohydrate
Synonyms:DMHM;(9α,13α,14α)-3-Methoxy-17-MethylMorphinan HydrobroMide Hydrate;3-Methoxy-17-Methyl-9α,13α,14α-Morphinan HydrobroMide Hydrate;d-3-Methoxy-N-MethylMorphinan HydrobroMide Monohydrate;DextroMethorphan hydrobroMide:Monohydrat;Morphinan,3-Methoxy-17-Methyl-, hydrobroMide, hydrate (1:1:1), (9a,13a,14a)-;D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE;DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE
CAS:6700-34-1
MF:C18H28BrNO2
MW:370.33
EINECS:629-741-3
Product Categories:Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs
Mol File:6700-34-1.mol
Dextromethorphan hydrobromide monohydrate Structure
Dextromethorphan hydrobromide monohydrate Chemical Properties
Melting point 116-119°C
alpha [α]D25 +26~+30° (c=1.85, H2O)
Fp 11 °C
storage temp. Store at RT
solubility Sparingly soluble in water, freely soluble in ethanol (96 per cent).
form solid
color White to Off-White
PHpH (10g/l, 25℃) : 5.2~6.5
BRN 6453793
InChIKeyQYPSYPPSHXDFLV-UHFFFAOYSA-N
LogP1.351 (est)
CAS DataBase Reference6700-34-1(CAS DataBase Reference)
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 7-16-36/37-45
WGK Germany 3
HS Code 3822000002
MSDS Information
Dextromethorphan hydrobromide monohydrate Usage And Synthesis
DescriptionDextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.
Chemical PropertiesWhite Solid
UsesAn antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).
UsesAntitussive;Opioid ligand
DefinitionChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan.
Brand nameBenylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).
Biological ActivityNon-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.
Dextromethorphan hydrobromide monohydrate Preparation Products And Raw materials
Tag:Dextromethorphan hydrobromide monohydrate(6700-34-1) Related Product Information
MELIBIOSE Dextromethorphan D-Glucose monohydrate Citric acid monohydrate 3-Isobutyl-1H-pyrazole-5-carboxylic acid 1,4,5,6-TETRAHYDRO-CYCLOPENTAPYRAZOLE-3-CARBOXYLIC ACID Ethyl 3-n-propylpyrazole-5-carboxylate 1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-CYCLOPROPYLPYRAZOLE-5-CARBOXYLIC ACID 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Dextromethorphan Hydrobromide INDAZOLE-3-CARBOXYLIC ACID Hydrogen bromide 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 1H-Pyrazole-3-carboxylicacid,1-methyl-5-propyl-,ethylester(9CI) 2-METHYL-4,5,6,7-TETRAHYDRO-2H-INDAZOLE-3-CARBOXYLIC ACID 4,5,6,7,8,9-HEXAHYDRO-1H-CYCLOOCTAPYRAZOLE-3-CARBOXYLIC ACID 1H-Pyrazole-3-carboxylicacid,1-methyl-5-propyl-(9CI)