化合物 T14546
| 中文名称 | 化合物 T14546 |
|---|---|
| 中文同义词 | 化合物 T14546 |
| 英文名称 | bermoprofen |
| 英文同义词 | 10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepine-2-acetic acid;AD-1590;2-(8-Methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)propionic;Brn 4815717;Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)-;10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID;AD-1590|||AJ-1590 |
| CAS号 | 78499-27-1 |
| 分子式 | C18H16O4 |
| 分子量 | 296.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 78499-27-1.mol |
| 结构式 |  |
化合物 T14546 性质
| 熔点 | 128-129° |
|---|---|
| 沸点 | 397.92°C (rough estimate) |
| 密度 | 1.1874 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | Store at -20°C |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
Bermoprofen (AD-1590) 是一种具有口服活性地非甾体类抗炎药。Bermoprofen 具有有效的解热和镇痛作用，且生物半衰期短。Bermoprofen 是 LPS 诱导的兔发烧的有效拮抗剂。
Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents.
Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits.
| Animal Model: | Male albino rabbits, 2.3-3 kg |
| Dosage: | 0.04, 0.4, 0.1 mg/kg |
| Administration: | Oral; given 1 h after i.v. injection of LPS |
| Result: | Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg. |
安全信息
| 毒性 | LD50 in mice, rats (mg/kg): 500, 147 orally (Nakamura) |
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上游原料