化合物 T14546
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- CAS号:
- 78499-27-1
- 英文名:
- bermoprofen
- 英文别名:
- AD-1590;Brn 4815717;AD-1590|||AJ-1590;10,11-DIHYDRO-α-8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID;2-(8-Methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)propionic;10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepine-2-acetic acid;Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)-
- 中文名:
- 化合物 T14546
- 中文别名:
- 化合物 T14546
- CBNumber:
- CB61383645
- 分子式:
- C18H16O4
- 分子量:
- 296.32
- MOL File:
- 78499-27-1.mol
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化合物 T14546化学性质
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熔点:
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128-129°
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沸点:
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397.92°C (rough estimate)
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密度:
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1.1874 (rough estimate)
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折射率:
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1.5400 (estimate)
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储存条件:
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Store at -20°C
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形态:
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Solid
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颜色:
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Off-white to light yellow
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化合物 T14546性质、用途与生产工艺
Bermoprofen (AD-1590) 是一种具有口服活性地非甾体类抗炎药。Bermoprofen 具有有效的解热和镇痛作用，且生物半衰期短。Bermoprofen 是 LPS 诱导的兔发烧的有效拮抗剂。
Bermoprofen (AD-1590) shows ulcerogenic activity as a side-effect like other nonsteroidal anti-inflammatory agents.
Bermoprofen (AD-1590) (0.04-0.1 mg/kg; p.o.) shows a dose-related antipyretic activity in LPS-induced febrile rabbits.
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Animal Model:
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Male albino rabbits, 2.3-3 kg
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Dosage:
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0.04, 0.4, 0.1 mg/kg
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Administration:
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Oral; given 1 h after i.v. injection of LPS
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Result:
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Inhibited significantly the rise in rectal temperature at doses of 0.1 mg/kg or more, the temperature returned approximately to normal after 0.4 mg/kg.
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化合物 T14546
上下游产品信息
上游原料
下游产品
78499-27-1, 化合物 T14546 相关搜索:
- 抑制剂
- 化合物 T14546
- 78499-27-1
- AD-1590|||AJ-1590
- -8-DIMETHYL-11-OXO-DIBENZ(b,f)OXEPIN-2-ACETIC ACID
- 10,11-DIHYDRO-&alpha
- Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)-
- Brn 4815717
- 2-(8-Methyl-10,11-dihydro-11-oxodibenz(B,F)oxepin-2-yl)propionic
- AD-1590
- 10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepine-2-acetic acid