| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:thielavin A
CAS:71950-66-8
Purity:>95% by HPLC Package:1mg;5mg
|
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:Thielavin A
CAS:71950-66-8
Purity:>95% by HPLC Package:1mg;5mg
|
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| | thielavin A Basic information |
| Product Name: | thielavin A | | Synonyms: | thielavin A;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester;Benzoic acid, 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-, 4-carboxy-3-hydroxy-2,5,6-trimethylphenyl ester | | CAS: | 71950-66-8 | | MF: | C29H30O10 | | MW: | 538.54 | | EINECS: | | | Product Categories: | | | Mol File: | 71950-66-8.mol |  |
| | thielavin A Chemical Properties |
| Melting point | 235-236 °C | | Boiling point | 850.0±65.0 °C(Predicted) | | density | 1.371±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: souble; DMSO: souble; Ethanol: soluble | | form | White to off-white powder. | | pka | 2.82±0.28(Predicted) |
| | thielavin A Usage And Synthesis |
| Description | Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM). | | Uses | Thielavin A acts as an inhibitor of prostagladins biosynthesis. | | Uses | The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor. |
| | thielavin A Preparation Products And Raw materials |
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