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DL-PROPARGYLGLYCINE

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Products Intro: Product Name:H-DL-Pra-OH
CAS:64165-64-6
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:H-DL-Pra-OH
CAS:64165-64-6
Purity:99% Package:1000g; 100g; 50g; 25g; 10g; 5g Remarks:Amino Acids & Derivatives
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Products Intro: Product Name:DL-PROPARGYLGLYCINE
CAS:64165-64-6
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Products Intro: Product Name:DL-PROPARGYLGLYCINE
CAS:64165-64-6
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:DL-PROPARGYLGLYCINE
CAS:64165-64-6
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg

DL-PROPARGYLGLYCINE manufacturers

  • DL-PROPARGYLGLYCINE
  • DL-PROPARGYLGLYCINE pictures
  • $10.00 / 1KG
  • 2019-07-06
  • CAS:64165-64-6
  • Min. Order: 10KG
  • Purity: 99%
  • Supply Ability: 100kg
DL-PROPARGYLGLYCINE Basic information
Product Name:DL-PROPARGYLGLYCINE
Synonyms:H-PROPARGYL-DL-GLYCINE;H-PROPARGYL-DL-GLY-OH;H-DL-PRA-OH;H-DL-GLY(PROPARGYL)-OH;DL-PROPARGYLGLYCINE;DL-PROPARGYL-GLY-OH;2-AMINO-4-PENTYNOIC ACID;NSC21940
CAS:64165-64-6
MF:C5H7NO2
MW:113.11
EINECS:
Product Categories:Amino Acids
Mol File:64165-64-6.mol
DL-PROPARGYLGLYCINE Structure
DL-PROPARGYLGLYCINE Chemical Properties
storage temp. -20°C
solubility Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
form Crystalline Powder
color White to off-white
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
DL-PROPARGYLGLYCINE Usage And Synthesis
DescriptionPropargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.
Chemical PropertiesWhite to off-white powder
UsesDl-propargylglycine is an inhibitor of hydrogen sulfide (H2S) production.
Synthesis Reference(s)Journal of the American Chemical Society, 76, p. 3484, 1954 DOI: 10.1021/ja01642a036
Tetrahedron Letters, 22, p. 1787, 1981 DOI: 10.1016/S0040-4039(01)90439-3
Biochem/physiol ActionsDL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).
References1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141
DL-PROPARGYLGLYCINE Preparation Products And Raw materials
Tag:DL-PROPARGYLGLYCINE(64165-64-6) Related Product Information
L-Propargylglycine (R)-METHYL-2-BOC-AMINO-4-PENTENOIC ACID (R)-N-BOC-Propargylglycine D-PROPARGYLGLYCINE METHYL-2-BOC-AMINO-4-PENTENOIC ACID (S)-N-BOC-Propargylglycine (R)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid (S)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid 4-PENTYNOIC ACID DL-PROPARGYLGLYCINE (S)-ALPHA-PROPYNYL-PROLINE-HCL H-PRA-OME HCL H-GLY-PRO-PNA HCL ACETYL-DL-PROPARGYLGLYCINE ETHYL ESTER H-ASP-PNA HCL (R)-ALPHA-PROPYNYL-PROLINE-HCL (R)-PROPARGYLGLYCINE METHYL ESTER HYDROCHLORIDE N-ACETYL-DL-PROPARGYLGLYCINE