4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚
中文名称 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 |
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中文同义词 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚;MCF-7细胞株抑制剂(YL-109);2-(4-羟基-3-甲氧基苯基)苯并噻唑;化合物YL-109 |
英文名称 | 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE |
英文同义词 | 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE;YL-109;4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol;Y109;Y-109;Y-109;Y109;4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one;4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol |
CAS号 | 36341-25-0 |
分子式 | C14H11NO2S |
分子量 | 257.31 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;细胞生物学试剂;Inhibitors |
Mol文件 | 36341-25-0.mol |
结构式 |
4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 性质
储存条件 | 2-8°C |
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溶解度 | DMF:30mg/mL; DMSO:30mg/mL; DMSO:PBS (pH 7.2) (1:9):0.1 mg/ml;乙醇:1mg/mL |
形态 | 结晶固体 |
颜色 | 浅黄至黄色 |
YL-109是新型的抗肿瘤试剂,在体内外可抑制乳腺癌细胞的生长和侵袭。
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
Cell Proliferation Assay
Cell Line: | MCF-7 and MDA-MB-231 cells |
Concentration: | 0.001, 0.01, 0.1, 1, 10 μM |
Incubation Time: | 96 hours |
Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). |
YL-109 (15 mg/kg; s.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.
Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells |
Dosage: | 15 mg/kg |
Administration: | S.c. every 2 days for 63 days |
Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-18619 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 YL-109 | 36341-25-0 | 5mg | 550元 |
2024/04/30 | S6607 | 4-(苯并[D]噻唑-2-基)-2-甲氧基苯酚 YL-109 | 36341-25-0 | 5mg | 795.41元 |