- Elocalcitol
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- $1320.00 / 5mg
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2024-10-28
- CAS:199798-84-0
- Min. Order:
- Purity:
- Supply Ability: 10g
- ELOCALCITOL
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- $7.00 / 1KG
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2020-02-14
- CAS: 199798-84-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100KG
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| | ELOCALCITOL Basic information |
| Product Name: | ELOCALCITOL | | Synonyms: | ELOCALCITOL;BXL 628;(1R,3E,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(E,2S)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol;Ellocalciferol;Cyclohexanol, 3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylene-, (1R,3Z,5S)-;Ro 26-9228 | | CAS: | 199798-84-0 | | MF: | C29H43FO2 | | MW: | 442.65 | | EINECS: | | | Product Categories: | | | Mol File: | 199798-84-0.mol |  |
| | ELOCALCITOL Chemical Properties |
| Boiling point | 568.3±50.0 °C(Predicted) | | density | 1.05±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Ethanol:20.0(Max Conc. mg/mL);45.18(Max Conc. mM) | | form | A crystalline solid | | pka | 14.04±0.40(Predicted) | | color | White to off-white | | optical activity | [α]/D +97 to +107°, c =c=1 in methanol |
| | ELOCALCITOL Usage And Synthesis |
| Description | BXL-628 is an analog of vitamin D3 that has diverse biological activities. It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner. In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis. BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis. Formulations containing BXL-628 are under clinical investigation for the treatment of BPH. |
| | ELOCALCITOL Preparation Products And Raw materials |
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