BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
| 中文名称 | BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 |
|---|---|
| 中文同义词 | BIOTIN-SUBSTANCE P,BIOTIN-RPKPQQFFGLM-NH2;BIOTIN-神经肽P物质;生物素标记P物质肽BIOTIN-SUBSTANCE P |
| 英文名称 | BIOTINYL-SUBSTANCE P |
| 英文同义词 | BIOTINYL-SUBSTANCE P;BIOTIN-SUBSTANCE P;BIOTIN-RPKPQQFFGLM-NH2;BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;substance P, alpha-biotinyl-Arg(1) -;Abasp;alpha-Biotinyl-1-Arg-substance p |
| CAS号 | 87468-58-4 |
| 分子式 | C73H112N20O15S2 |
| 分子量 | 1573.93 |
| EINECS号 | |
| 相关类别 | 多肽;标准品;peptide |
| Mol文件 | 87468-58-4.mol |
| 结构式 |  |
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble in water at 2mg/ml; also soluble in acetonitrile |
Biotin-Substance P (Neurokinin P) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.