异紫堇定碱
中文名称 | 异紫堇定碱 |
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中文同义词 | 右旋异紫堇定;异紫堇定碱,右旋异紫堇定;异紫堇定碱;盐酸异紫堇定;异紫堇碱;ARTABOTRIN|||S-ISOCORYDINE(+)|||异紫堇定|||LUTEANIN|||UZOKORIDIN|||(+)-ISOCORYNOLINE |
英文名称 | ISOCORYDINE HYDROCHLORIDE |
英文同义词 | LUTEANINE;LUTEANINE HYDROCHLORIDE;1,2,10-trimethoxy-6a-alpha-aporphin-11-o;4h-dibenzo(de,g)quinolin-11-ol,5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methy;artabotrin;d-isocorydine;l-(+)-isocorydine;luteanin |
CAS号 | 475-67-2 |
分子式 | C20H23NO4 |
分子量 | 341.4 |
EINECS号 | |
相关类别 | 小分子抑制剂,天然产物;植物提取物;小分子抑制剂;标准品;中药对照品;标准品 -中药标准品;对照品-中药对照品;Miscellaneous Natural Products;Alkaloids;Inhibitors;精细化工;生物碱 |
Mol文件 | 475-67-2.mol |
结构式 | ![]() |
异紫堇定碱 性质
熔点 | 216-220 °C(lit.) |
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比旋光度 | D20 +195° (chloroform) |
沸点 | 477.03°C (rough estimate) |
密度 | 1.2064 (rough estimate) |
折射率 | 1.5614 (estimate) |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 水晶。 |
酸度系数(pKa) | 9.41±0.20(Predicted) |
Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387. Isocorydine (0-400 ug/ml; 48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines.
Cell Viability Assay
Cell Line: | Huh-7, Hep-G2 , SNU-387, SNU-449 cells |
Concentration: | 0-400 ug/ml |
Incubation Time: | 24 hours |
Result: | Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone. |
Western Blot Analysis
Cell Line: | Huh-7, Hep-G2 , SNU-387, SNU-449 cells |
Concentration: | |
Incubation Time: | 24 hours |
Result: | Downregulated protein levels of Claundin-1 and E-cadherin. |
Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth.
Animal Model: | Female nude mice |
Dosage: | 0.4 mg/ml |
Administration: | Injected intraperitoneally every 2 days for 2 weeks |
Result: | Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC. |
安全信息
WGK Germany | 3 |
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RTECS号 | CE1057950 |
毒性 | LD50 intraperitoneal in mouse: 104mg/kg |