GlyH-101

GlyH-101 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:GlyH101
CAS:328541-79-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:GlyH-101
CAS:328541-79-3
Purity:>98% Package:25mg Remarks:BOC Sciences also provides custom synthesis services for GlyH-101.
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name: (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
CAS:328541-79-3
Purity:99% Package:1g;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:GlyH-101;GlyH 101;GlyH101
CAS:328541-79-3
Purity:97.26% Package:1 mL * 10mM (in DMSO);10 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:GlyH-101
CAS:328541-79-3
Purity:98% Package:2mg Remarks:V20997

GlyH-101 manufacturers

GlyH-101 Basic information
Product Name:GlyH-101
Synonyms:(NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE;GLYH-101;Glycine, N-2-naphthalenyl-, [(3,5-dibroMo-2,4-dihydroxyphenyl)Methylene]hydrazide;N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;GlyH 101 N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101
CAS:328541-79-3
MF:C19H15Br2N3O3
MW:493.15
EINECS:
Product Categories:Inhibitors;CFTR Inhibitor II, GlyH-101 is a cell-permeable glycinyl hydrazone compound.
Mol File:328541-79-3.mol
GlyH-101 Structure
GlyH-101 Chemical Properties
Melting point >300℃ (ethanol )
density 1.73±0.1 g/cm3(Predicted)
storage temp. = -70C
solubility DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM)
DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM)
form Yellow solid
pka5.44±0.45(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
GlyH-101 Usage And Synthesis
DescriptionThe cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 μM). This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport. Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin. It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.
UsesN-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.
DefinitionChEBI: Glycine, n-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a member of naphthalenes.
General DescriptionA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
Biochem/physiol ActionsCell permeable: yes
storageStore at -20°C
GlyH-101 Preparation Products And Raw materials
Tag:GlyH-101(328541-79-3) Related Product Information
GlyH-101