F 11440
中文名称 | F 11440 |
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中文同义词 | 4-甲基-2- [4- [4-(2-嘧啶基)-1-哌嗪基]丁基] -1,2,4-三嗪-3,5(2H,4H) - 二酮;F 11440游离态;化合物EPTAPIRONE;4-甲基-2-(4-(4-(嘧啶-2-基)哌嗪-1-基)丁基)-1,2,4-三嗪-3,5(2H,4H)-二酮 |
英文名称 | EPTAPIRONE |
英文同义词 | EPTAPIRONE;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;F 11440;4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;F-11440;F11440;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Eptapirone(F11440);Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440 |
CAS号 | 179756-58-2 |
分子式 | C16H23N7O2 |
分子量 | 345.4 |
EINECS号 | |
相关类别 | |
Mol文件 | 179756-58-2.mol |
结构式 |
F 11440 性质
沸点 | 517.4±60.0 °C(Predicted) |
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密度 | 1.35±0.1 g/cm3(Predicted) |
储存条件 | Inert atmosphere,Room Temperature |
溶解度 | DMF:10.0(最大浓度 mg/mL);28.95(最大浓度 mM) |
形态 | 结晶固体 |
酸度系数(pKa) | 7.72±0.10(Predicted) |
颜色 | 白色至米白色 |
5-HT 1A Receptor
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The affinity of Eptapirone (F11440) for 5-HT1Abinding sites (pKi, 8.33) was higher than that of buspirone (pKi , 7.50), and somewhat lower than that of flesinoxan (pKi , 8.91).In vivo, Eptapirone (F11440) was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). Eptapirone (F11440), shown here to be a potent, selective, high efficacy 5-HT1Areceptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.[1]
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-19946 | Eptapirone | 1 mg | 300元 | |
2024/08/19 | HY-19946 | F 11440 Eptapirone | 179756-58-2 | 5mg | 800元 |