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| | 7-Nitro-1,2,3,4-tetrahydroquinoline Basic information |
| Product Name: | 7-Nitro-1,2,3,4-tetrahydroquinoline | | Synonyms: | 7-Nitro-1,2,3,4-Terahydroquinoline;1,2,3,4-TETRAHYDRO-7-NITROQUINOLINE;7-NITRO-1,2,3,4-TETRAHYDROQUINOLINE;7-NITRO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE;7-Nitro-1,2,3,4-tetrahydroquinoline
1,2,3,4-Tetrahydro-7-nitroquinoline;Quinoline, 1,2,3,4-tetrahydro-7-nitro-;7-Nitro-1,2,3,4-tetrahydroquinoline>;7-Nitro-1,2,3,4-tetrahydroquinoline,95% | | CAS: | 30450-62-5 | | MF: | C9H10N2O2 | | MW: | 178.19 | | EINECS: | 634-828-4 | | Product Categories: | Quinoline&Isoquinoline | | Mol File: | 30450-62-5.mol |  |
| | 7-Nitro-1,2,3,4-tetrahydroquinoline Chemical Properties |
| Melting point | 61.0 to 65.0 °C | | Boiling point | 325.2±31.0 °C(Predicted) | | density | 1.236±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | 3.44±0.20(Predicted) | | form | Powder | | color | Red | | CAS DataBase Reference | 30450-62-5(CAS DataBase Reference) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | HS Code | 2933499090 |
| | 7-Nitro-1,2,3,4-tetrahydroquinoline Usage And Synthesis |
| Uses | 7-Nitro-1,2,3,4-tetrahydroquinoline is a quinoline compound that can be used as a reagent in chemical reactions or as an intermediate in organic synthesis. It can be used to prepare 7-Aminoquinoline and 7-Nitroquinoline. | | Synthesis | 7-Nitro-1,2,3,4-tetrahydroquinoline is synthesised by the reaction of 1,2,3,4-tetrahydroquinoline and nitric acid in sulphuric acid solution. The specific synthesis steps are as follows:
Concentrated sulfuric acid (30.00 mL) was cooled to -10° C. with an ice/salt bath.
To this, 1,2,3,4-tetrahydro-quinoline (10.60 g, 75.60 mmol) and a solution of nitric acid (99.5percent, 4.80 g, 75.60 mmol) in sulfuric acid (15.00 mL) were added simultaneously within 1 hour, so that the temperature of the reaction mixture does not exceed 10° C.
The mixture was stirred then for 2.5 hours at -5° C., then poured over ice and treated with sodium carbonate (0.10 kg) until pH 8-9 was reached.
The solid was filtered, washing with water, then dissolved in dichloromethane.
The organic phase was washed with water, dried over magnesium sulphate and evaporated.
7-Nitro-1,2,3,4-tetrahydro-quinoline was obtained as a viscous brown oil, 13.70 g (85percent), 84percent purity.
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| | 7-Nitro-1,2,3,4-tetrahydroquinoline Preparation Products And Raw materials |
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