Nsc264136
| 中文名称 | Nsc264136 |
|---|---|
| 中文同义词 | 化合物 T10200 |
| 英文名称 | Nsc264136 |
| 英文同义词 | Nsc264136;9-Hydroxyellipticine, Hydrochloride;9-hydroxyellipticine HCl salt;5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol hydrochloride;9Hydroxyellipticine hydrochloride,9 Hydroxyellipticine hydrochloride |
| CAS号 | 52238-35-4 |
| 分子式 | C17H15ClN2O |
| 分子量 | 298.7668 |
| EINECS号 | |
| 相关类别 | Other Enzyme Inhibitors and Activators. |
| Mol文件 | 52238-35-4.mol |
| 结构式 |  |
Nsc264136 性质
| 熔点 | >223oC (dec.) |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | DMSO（微溶，加热）、甲醇（微溶超声处理） |
| 形态 | 固体 |
| 颜色 | 橙色至深橙色 |
9-Hydroxyellipticine hydrochloride 是 Topo II 和RyR 的抑制剂。9-Hydroxyellipticine hydrochloride 具有抗肿瘤、抗氧化和释放儿茶酚胺的活性。 9-Hydroxyellipticine hydrochloride 对 Hela S-3 和293T 细胞的IC50 值分别为1.6 μM 和1.2μM。
|
Topoisomerase II
|
9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM.
9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells.
| Animal Model: | Three- to five-month-old C57B1/6 male mice. |
| Dosage: | 5 or 10 mg/kg. |
| Administration: | IP. |
| Result: | Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells. |