化合物 T22044
| 中文名称 | 化合物 T22044 |
|---|---|
| 中文同义词 | 化合物 T22044 |
| 英文名称 | 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine |
| 英文同义词 | 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine;BGC 20-761;1H-Indole-3-ethanamine, 5-methoxy-N,N-dimethyl-2-phenyl- |
| CAS号 | 17375-63-2 |
| 分子式 | C19H22N2O |
| 分子量 | 294.39 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 17375-63-2.mol |
| 结构式 |  |
化合物 T22044 性质
| 沸点 | 489.2±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.114±0.06 g/cm3(Predicted) |
| 储存条件 | Store at +4°C |
| 溶解度 | <14.72mg/ml，在乙醇中； <29.44mg/ml，溶于 DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 16.74±0.30(Predicted) |
| 颜色 | 白色 |
|
Human 5-HT 6 Receptor 20 nM (Ki) |
Human 5-HT 2A Receptor 69 nM (Ki) |
Human D 2 Receptor 140 nM (Ki) |
BGC20-761 has highly potent and selective 5-HT6 receptor antagonist activity; rat K i values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM).
BGC20-761 enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. BGC20-761 (2.5 mg/kg, 5 mg/kg and 10 mg/kg; i.p.) alone has no effect on social recognition in young rats, however, at doses of 5 mg/kg and 10 mg/kg i.p, BGC20-761 dose-dependently reverses a deficit of social recognition induced by Scopolamine (0.4 mg/kg i.p.).
| Animal Model: | Forty-two male 8-week-old Longe Evans rats and 12 male four-week-old SpragueeDawley rats |
| Dosage: | 2.5 mg/kg, 5 mg/kg and 10 mg/kg |
| Administration: | Administered (i.p.) immediately after the training session for the social recognition test |
| Result: | Administered alone did not show any difference in social recognition as compared to saline treated control animals. However, 5 mg/kg and 10 mg/kg reversed a Scopolamine induced deficit in social recognition. |