| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:BGC 20-761;5-Methoxy-N,N-diMethyl-2-phenyl-1H-indole-3-ethanaMine
CAS:17375-63-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:BGC 20-761
CAS:17375-63-2
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
|
| | 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Basic information |
| | 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Chemical Properties |
| Boiling point | 489.2±45.0 °C(Predicted) | | density | 1.114±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | <14.72mg/ml in ethanol; <29.44mg/ml in DMSO | | form | solid | | pka | 16.74±0.30(Predicted) | | color | White |
| | 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Usage And Synthesis |
| Uses | BGC 20-761, is a selective high affinity 5-HT6 antagonist (Ki = 20 nM). that has shown to enhance memory consolidation in a rat model. It reverses he amnesic effects of Scopolamine (S200000). | | Biological Activity | bgc20-761 is a selective and high affinity antagonist of 5-htc.the 5-ht6 receptor, a g protein-coupled receptor (gpcr), is a subtype of 5-ht receptor which binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-ht). this protein is expressed almost exclusively in the brain and mediates excitatory neurotransmission.in cellular level, bgc20-761 (5-methoxy-2-phenyl-n,n-dimethyltryptamine) was shown to selectively blocked 5-htc.bgc20-761 was used to study the difference in drug- induced effects in memory consolidation in young and mature rats and human. in young mice, bgc20-761 treatment at doses of 5 mg/kg and 10 mg/kg i.p, dose-dependently reversed a deficit of social recognition induced by scopolamine, an anticholinergic drug that impairs memory at dosage of 0.4 mg/kg i.p. in mature rats (6 months), recognition of the novel object was improved following administration of bgc20-761. the difference in effects of bgc20-761 in young vs. mature rats may reflect the status of memory consolidation in these different age ranges 1. | | storage | Store at +4°C | | references | 1. mitchell es, hoplight bj, lear sp, et al. bgc20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-ht6 receptor-mediated mechanism. neuropharmacology. 2006;50(4):412-420. |
| | 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine Preparation Products And Raw materials |
|